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Transformed cells derived from human tumors show partial resistance toMDM2-mediated G1-arrest showing a slower rate of cell cycle transition [ 67 ].Consistently, non-transformed cells do not show stable overexpression of MDM2from its cDNA suggesting that cells overexpressing MDM2 do not multiply. (2000) The Mental Status Examination inNeurology, 4th edn. Li M et al (2002) Acetylation of p53 inhibits its ubiquitination by Mdm2.

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